CBD from hemp (CBD) can be described as a chemical that is derived from hemp that doesn’t, in itself, create a “high” according to a report from Harvard Health. There are many questions about what health benefits of CBD and if there are there are any. There isn’t a conclusive proof to support the claim that CBD can provide advantages. There are studies conducted in various fields, however, these studies aren’t conclusive, and further studies and clinical trials are needed.


There are numerous studies looking at whether CBD can have neurological benefits including aiding in the treatment of anxiety disorders. A study published in Aerotherapeutics review “CBD’s potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies.” The researchers found evidence that supports “CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing.”

Another (small) study conducted in 2010 that was released in the Journal of Psychopharmacology assessed whether Hemp CBD might help in the treatment of the disorder of social anxiety (SAD). Researchers concluded that the findings from the research “suggest that CBD reduces anxiety in SAD and that this is related to its effects on activity in limbic and Para limbic brain areas.”


A study published by Permanente, and entitled Cannabidiol in the treatment of anxiety and sleep The Large Case Study examined the possibility that CBD helps alleviate anxiety and sleep in a population of clinical patients. The study concluded “The final sample was comprised of 72 people who had main anxiety concerns (n =47) or sleep issues (n 25). Stress scores declined over the first month for the 57 participants (79.2 percent) and then decreased over the duration of the study. Sleep scores improved over the first month for 48 patients (66.7 percent) however they changed over time. In this review of charts, CBD was well tolerated for all patients, with the exception of 3.” Yet, the study was also acknowledged that “controlled clinical trials are required.”

Mobility and pain among patients with Multiple Sclerosis

A study that was published within Frontiers in Neurology reviewed 132 original research papers. Researchers concluded they believed that “it is our opinion that CBD supplementation maybe advisable for PwMS to reduce fatigue, pain, spasticity, and ultimately improve mobility.” It is crucial to emphasize this study is confined to patients with MS, and that correlation doesn’t necessarily mean that there is a causal link.

Another study that was published in National Library of Medicine, examined the effects of CBD on inflammation pain in rodents. The study concluded that “atypical cannabinoid receptors are involved in joint nociception and these novel targets may be advantageous for the treatment of inflammatory pain.”

Chronic Pain Management

A study from 2008 titled Cannabinoids for managing difficult-to-treat pain reviewed “recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment.” The review suggested CBD could play an important role in the management of chronic pain.

Severe Forms of Epilepsy

In the year 2018 The U.S. Food and Drug Administration approved the pharmaceutical drug Epidiolex with cannabidol in treatments for severe cases epilepsy. In a press release regarding the approval, the FDA said: “The U.S. Food and Drug Administration today approved Epidiolex (cannabidiol) [CBD] oral solution for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients two years of age and older.” It is the sole FDA-recommended product with CBD.

The FDA also states that adverse symptoms were experienced by patients who had been who were treated with Epidiolex such as “sleepiness, sedation and lethargy; elevated liver enzymes; decreased appetite; diarrhea; rash; fatigue, malaise and weakness; insomnia, sleep disorder and poor quality sleep; and infections.”

Bottom Line: Not Enough Evidence and More Research Needed

There are ongoing studies on the possible advantages of hemp-derived CBD but there isn’t enough evidence to provide a definitive answer on whether CBD may help in the mentioned conditions.

According to Brent Bauer, M.D. is Director of Research and an internist for the Mayo Clinic Integrative Medicine program revealed in a Mayo Clinic news report titled CBD products hemp oil might be beneficial, but more research is required. Mayo Clinic review says, “There are many intriguing findings in pre-clinical studies that suggest CBD and hemp oil have anti-inflammatory effects and may be helpful with improving sleep and anxiety.” He went on to say, “But trials in humans are still limited, so it is too early to be definitive about efficacy and safety.”

The information provided is intended for general educational and informational purposes only. It is not intended to be taken as a legal or wellness recommendation.

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